Philippine E-Journals

SGPT level in Paracetamol-Induced Rabbits Treated with Formulated Capsule from Turmeric Rhizome (Cucurma longa) Ethanolic Extract

Sonia S. Morales | Orcheliza L. Paramo | Jenny Rose C. Babon | April D. Bagundol | Charizel Mea S. Baweg | Irah A. Borbon | Neffretteree P. Cabangon | Arabelle Kristine D. Capito | Krisna Mae M. Estimo | Efraim M. Oliva | John A. Rideout

 

Abstract:

Liver disease is a range of conditions and associated symptoms that develop when the liver becomes damaged. Taking Paracetamol is one cause of liver damage because it is popular as over-the-counter drug that can easily be bought by the people. To address this issue, analysis of the liver damage through the level of Serum Glutamate Pyruvate Transaminase (SGPT) was done in this study using turmeric rhizome (Curcuma longa). A phytochemical screening was primarily performed and revealed to have flavonoids. Acute oral toxicity test was employed as a protocol if safe for formulation. This reveals to be non-toxic based on the OECD 423 guidelines at 2000 mg/kg body weight of rabbit. The Approximate Effective Dose (AED) level of Turmeric rhizome is 68.094 mg/kg which is the high dose. Analysis of Variance for SGPT levels between test extract and positive control showed no significant difference. It means that the activity of turmeric rhizome is comparable to essential (positive control). Therefore, the Turmeric rhizome formulated capsule can lower the SGPT level of the paracetamol induced rabbits under the experimental condition. This study suggests that the Curcuma longa will be subjected for further investigation using pathological procedure and Effective Dose (ED90) for additional information on the SGPT lowering potential of the plant material.