ANTI-ANGIOGENIC PROPERTY OF TURMERIC PLANT (CURCUMA LONGA LINN) IN THE DUCK EMBRYO

Adorico  M. Aya-ay,; Elsie  M. Berdigar,; Liesel Melody  R. Galay,; Maverick John  F. Gresones,; Ruth Louise  Y. Mabalot,; Kriska Jaye  I. Resgonia,

ANTI-ANGIOGENIC PROPERTY OF TURMERIC PLANT (CURCUMA LONGA LINN) IN THE DUCK EMBRYO

Abstract:

Angiogenesis is the formation of new blood vessels which involves the migration, growth, and differentiation of endothelial cells and is controlled by chemical signals in the body. It plays a critical role in the anti-angiogenic property of turmeric leaf and rhizome extract. It utilized an experimental-control group which used Simvastatin, a known angiogenic inhibitor as the positive control and distilled water as the negative control. The study utilized chorioallantoic membrane assay employing the use of freshly laid duck eggs pre-incubated for 24 hours. Different concentrations of turmeric leaf and rhizome extracts were dispensed to the chorioallantoic membrane. The eggs were incubated for 7 days. After the incubation period, the eggs were cracked open and the embryos were placed in the petri dish. The major blood vessels were counted and the embryo structures were noted. Results showed that the turmeric leaf and rhizome extract exhibited anti-angiogenesis which is comparable to the positive control (p> .05) for both the turmeric leaf and rhizome extracts.