Philippine E-Journals

A META-ANALYSIS OF SILVER NANOPARTICLES ENHANCED AMPICILLIN AGAINST ANTIMICROBIAL RESISTANT PSEUDOMONAS AERUGINOSA

Wilbert Sevilla | Irish Mie De Torres | Marty Jeanne Jose | Haidie Maliksi | Geramie Joyce Ramos | Iessa Alexandra Viray | Supachai A. Basit | Geraldine B. Dayrit

 

Abstract:

A meta-analysis was performed to differentiate the efficacy of silver nanoparticles enhanced ampicillin compared to ampicillin against antimicrobial resistant Pseudomonas aeruginosa. A thorough search in different databases such as Google Scholar, PubMed, ResearchGate, Directory Open Access Journal (DOAJ), and ScienceDirect from 1998 until 2020 identified 256 articles, 9 of which were included in meta-analysis study random effects. The meta-analysis shows that there is a significant difference coefficient of 3.19 with 4 degrees of freedom and a p value of 0.001 in the zone of inhibition (ZOI), while in minimum inhibitory concentration (MIC) showed a significant difference coefficient of 7.37 with 1 degree of freedom and a p value of 0.60 and the null hypothesis is accepted.