HomeThe Philippine Journal of Biochemistry and Molecular Biology (PJBMB)vol. 2 no. 1 (2021)

Philippine Marine Sediment-Derived Actinomycetes: The New Frontier in Antibiotic Discovery

Doralyn S Dalisay

 

Abstract:

The marine sediments in the Philippine archipelago harbors diverse actinomycetes that potentially yield new core structures with antibiotic activities against multidrug-resistant pathogens. Since 2017, the Center for Chemical Biology and Biotechnology (C2B2) of the University of San Agustin, Iloilo City explored the Philippine marine environment for actinomycetes thriving in the seafloor. Currently, the C2B2 has a library of more than 3,000 marine sediment-derived actinomycetes, which now comprise the biobank for antibiotic discovery in the country. This lecture highlights the discovery of these biodiverse actinomycetes as well as the antibiotics they produce utilizing various experimental techniques that meld the disciplines of genomics, molecular biology, chemical biology, biotechnology, natural products chemistry, and metabolomics. Plenary Session—Oral