Antimicrobial Activity and COX-2 Modulatory Effects of Tetrahydrobisbenzylisoquinoline Alkaloids from Phaenthus ophthalmicus: Validation of Ethnomedicinaluse from in vitro and in silico Perspectives
Joe Anthony H. Manzano | Holbert D. Magpantay | Ivane N. Malaluan | Mark Tristan J. Quimque | Grecebio Jonathan D. Alejandro | Allan Patrick G. Macebeo
Abstract:
Under certain circumstances, microorganisms gain entry to the eye allowing infections to occur. Common pathogenic bacteria that cause eye infections are Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Hemophilus influenza, and Klebsiella species [1]. Among inflammatory bacterial infections, conjunctivitis (red eye) is often caused by staphylococcal or streptococcal bacteria from the skin or respiratory system. Drug development of efficient and cost-effective treatment modalities for bacterial infections remains an interesting field in disease drug discovery due to the rapid emergence of drug-resistant strains. Therefore, the development of safe and effective natural products is warranted to curb the emergence and re-emergence of these pathogens.
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