Antimutagenic Effects of Some Anticancer Agents

C.y.  Lim-sylianco,; F.  Blanco,

Antimutagenic Effects of Some Anticancer Agents

Discipline: subjects allied to medicine

Abstract:

Amygdalin, cyclophosphamide, and decoction of leaves of Catharanthus roseus (Linn.) Don. were studied as regards to their antimutagenic effects, using the micronucleus technique. The test mutagens that were employed were dipyrone, metronidazole, mitomycin C and safrole. Amygdalin, cyclophosphamide, and decoction from leaves of Catharanthus roseus (Linn.) Don. reduced the number of micronucleated polychromatic erythrocytes caused by the test mutagens. Highest antimutagenic effect was observed with decoction from leaves of Catharanthus roseus (Linn.) Don. Weakest effect was given by cyclophosphamide. An intermediate effect was shown by amygdalin.

References:

Sylianco, C. Y. L., & Brion, L. C. (1976). Effect of some vitamins on the mutagenicity of dimethylnitrosamine. Natural and Applied Science Bulletin, 28(4), 299–302.
Voogd, C. E., Vanderstel, J. S., & Jacobs, J. A. (1974). The mutagenic action of nitroimidazoles. Mutation Research/Environmental Mutagenesis and Related Subjects, 26(6), 483–490.
Rustia, M., & Shubik, P. (1972). Induction of lung tumors and malignant lymphomas in mice by metronidazole. Journal of the National Cancer Institute, 48(3), 721–729.
Windholz, M., Budavari, S., Stroumtsos, L. Y., & Fertig, M. N. (Eds.). (1976). The Merck index: An encyclopedia of chemicals and drugs (9^th ed., p. 633). Merck & Co., Inc.
Wodinsky, I., & Swinarski, H. (1975). Antitumor activity of metronidazole as a single agent or in combination with radiation or radiation and chemotherapeutic agents. Cancer Chemotherapy Reports. Part 1, 59(5), 939–944.
Arrighi, F. E., Hsu, T. C., & Bergsagel, D. E. (1962). Chromosome damage in murine and human cells following treatment with chemical agents. Texas Reports on Biology and Medicine, 20, 525–549.
DuFrain, R. J., Littlefield, L. G., & Wilmer, J. L. (1979). Evaluation of sister chromatid exchange in human lymphocytes as an indicator of mutagenic exposure. Environmental Mutagenesis, 1(4), 283–286.
National Science Development Board. (1980). Philippine national formulary (Part II). National Science Development Board.
Au, W. W., Johnston, D. A., Collie-Bruyere, C. C., & Hsu, T. C. (1980). Short-term cytogenetic assays of nine chemicals with a battery of in vivo and in vitro systems. Environmental Mutagenesis, 2(4), 455–464.
Schmid, W. (1977). The micronucleus test. Mutation Research/Environmental Mutagenesis and Related Subjects, 31(1), 9–15.
Kobayashi, J. (1960). Cytological studies of the effects of radiation on tumor cells: III. Effect of nitrous oxide on the mitotic cells of the Ehrlich ascites tumor. Cytologia, 25(2), 280–288.
Sylianco, C. Y. L., San Agustin, J., & Panizares, I. (1979). Antimutagenic effects of some Philippine medicinal plants. National Research Council of the Philippines (NRCP) Research Bulletin, 34(2), 151–155.