Inhibitory Effects of Butylated Hydroxyanisole and Butylated Hydroxytoluene on the Genotoxicity of Some Anticancer Drugs
C.y. Lim-sylianco | E. Evallo | B.c.t Bascug | C.h Parugganan
Abstract:
Busulfan, chlorambucil and cyclophosphamide, the three anticancer agents, did not
exrubit direct DNA damaging capacity in in vitro test using the Rec assay. However,
in vivo studies using the micronucleus test, showed that these drugs are mutagenic and
clastogenic.
Two antioxidants, butylated hydroxyanisole and butylated hydrozytoluene reduced
the genotox.ic effects of the three enticancer agents as shown by the significant reduction
of micronucleated polychromatic erythrocytes in bone marrow cells of mice.
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